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KMID : 1161420150180060625
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Journal of Medicinal Food
2015 Volume.18 No. 6 p.625 ~ p.630
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Impact of Cyclodextrins on Postprandial Glycemia: Evaluation in Experimental Animal Model Using the Real-Time Continuous Glucose Monitoring System
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Sybuia Mauricio Fumio
Guilhermetti Marcio
Mangolim Camila Sampaio
Bazotte Roberto Barbosa
Matioli Graciette
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Abstract
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The impact of cyclodextrins (CDs) on postprandial glycemic response employing the real-time continuous glucose monitoring system (RT-CGMS) was investigated. For this purpose, α-CD, β-CD, γ-CD, HP-β-CD, curdlan, and dextrin at doses of 10 and 100?mg/kg were orally administered in rats. The RT-CGMS was efficient to evaluate the impact of CDs on postprandial glycemia. The results showed that α-CD, β-CD, dextrin, and curdlan did not reduce the glycemic response after the administration of starch. In contrast, the HP-β-CD (100?mg/kg) attenuated the rise in glycemia. Moreover, the γ-CD blunts the postprandial glycemic excursion at doses of 10 and 100?mg/kg. Therefore, γ-CD could attenuate the rise in glycemia promoted by oral administration of starch. Considering that the treatment of postprandial hyperglycemia is necessary to prevent type 2 diabetes, this study opens the perspective of better control of postprandial glycemia by the addition of γ-CD in food.
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KEYWORD
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acarbose, cyclic oligosaccharides, glycemic control, postprandial glycemic response
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